SAMe (S-Adenosyl-L-Methionine) by Bioclinic Naturals supports joint health and emotional well-being.
Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation, and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefits for neurodegenerative disease, and potentially for improving endothelial function.